Abstract for presentation at 11th International Congress of Human Genetics

A Comparison Study of Renin and Angiotensin AIILevels in Normotensive Glaucoma Patients and Normal Individuals

  • Dr Hongmin Yun, Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Prof Pei Fu, Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Dr Xiaoxin Li, Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Prof Kexi Ding
  • Wei Wang, China

    • A local renin-angiotensin system (RAS) has been identified in human eyes and, specifically, RAS components have been found in human ciliary bodies and aqueous humour, pointing to a role of RAS in the regulation of aqueous humour dynamics. It has been hypothesized that the effect of the RAS is mediated predominantly by its ability to alter vascular tone in the human eye. Several investigations have indicated that an abnormality of regulation in aqueous humour dynamics is involved in the pathogenesis of the glaucomatous damage in normotensive glaucoma (NTG). Vascular factors can be subdivided into systemic and local vascular risk factors. Optic nerve blood flow may be affected by vasospasm and the association between vasospastic disorders and NTG may provide clues to the mechanisms of damage. In this study we investigated the levels of RAS components in NTG patients and normal individuals to determine if there are abnormalities of RAS in NTG patients.

    Conference Organiser - ICMS Pty Ltd