Abstract for presentation at 11th International Congress of Human Genetics

Prospective study of 174 Chinese de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations

  • Dr Liming Bao, Cincinnati Children's Hospital Medical Center and University of Cincinnati, United States
  • Dr Xiaoqin Wang, Huashan Hospital of Fudan University, China
  • Dr John Ryder, University of Colorado Health Sciences Center, United States
  • Dr Richard Irons, University of Colorado Health Sciences Center, US, United States
  • Dr Yan Chen, Sino-US Joint Clinical and Molecular Laboratory of Fudan University, China
  • Mrs Hui Chen, Sino-US Joint Clinical and Molecular Laboratory of Fudan University,, China
  • Mr Yongchen Yang, Sino-US Joint Clinical and Molecular Laboratory of Fudan University,, China
  • Dr Hui Fu, School of Public Health of Fudan University, China

    • We report for the first time a prospective study of 174 adult de novo acute myeloid leukemias diagnosed using the WHO classification in China. Of those, 57 (33%) were AML with recurrent cytogenetic abnormalities, 41 (24%) were AML with multilineage dysplasia, 74 (42%) were AML not otherwise categorized, and 2 were acute leukemias of ambiguous lineage. Clonal cytogenetic and FISH analyses yielded informative results in 95% of the AML patients, of which 64% had clonal abnormalities. The common clonal abnormalities included t(15;17) (15%), t(8;21) (12%), +8 (11%), -7/del7q (8%) and del9q (5%). The FLT3/ITD mutations (FMS-like tyrosine kinase 3/internal tandem duplication) were observed in 12% of the WHO AML cases, this frequency is much lower than reported in the literature, while the 6% incidence of the FLT3 activating loop mutations (either FLT3/D835 or FLT3/I836) was comparable with others. Both FLT3 mutations were associated with leukocytosis. Cytogenetic features of the WHO AML were compared with their FLT3 mutation statuses. Our study suggests that the FLT3 mutations are biomarkers independent of cytogenetic characteristics.

    Conference Organiser - ICMS Pty Ltd