Abstract for presentation at 11th International Congress of Human Genetics

Genetic Etiology of Autism: A Review

  • Dr K Manjunatha, National Institute of Mental Health and Neurosciences, India
  • Dr G Chetan, National Institute of Mental Health and Neurosciences, India
  • Mr H Venkatesh, National Institute of Mental Health and Neurosciences, India
  • Mrt Siddharth Roy, National Institute of Mental Health and Neurosciences, India
  • Mr Sam Balu, National Institute of Mental Health and Neurosciences, India
  • Mr E Venkataswamy, National Institute of Mental Health and Neurosciences, India

    • Genetic screening among 200 subjects with Autism revealed an array of genetic association especially the Autosomal Fragile sites, Fragile X chromosome, variant polymorphic chromosomes, Inv (9) and Autosomal translocations. The present study reviews the implications of the various fragile sites on Chromosomes 2q21, 2q23, 3p14, 4q31, 5q31, 6p23, 6q26, 7p11, 12q24, 15q22, Xq22, Xq26 and Xq27.3. Our study reveals that nearly 10% of the Autistic spectrum disorders (such as PDD, Rett’s Syndrome and Aspergers Syndrome ) shows genetic association with the fragile sites. The studies would help us to look for candidate genes at the vicinity of aberrations especially on 2, 3, 7, 15 and X chromosomes, for further delineation of genetic etiology for autism.

    Conference Organiser - ICMS Pty Ltd